About Chromates & Toxicity
The LD50 for chromium(VI) ranges between 50 and 150 mg/kg.In the body, chromium(VI) is reduced by several mechanisms to chromium(III) already in the blood before it enters the cells. The chromium(III) is excreted from the body, whereas the chromate ion is transferred into the cell by a transport mechanism, by which also sulfate and phosphate ions enter the cell. The acute toxicity of chromium(VI) is due to its strong oxidational properties. After it reaches the blood stream, it damages the kidneys, the liver and blood cells through oxidation reactions. Hemolysis, renal and liver failure are the results of these damages. Aggressive dialysis can improve the situation.
The carcinogenity of chromate dust is known for a long time, and in 1890 the first publication described the elevated cancer risk of workers in a chromate dye company. Three mechanisms have been proposed to describe the genotoxicity of chromium(VI). The first mechanism includes highly reactive hydroxyl radicals and other reactive radicals which are byproducts of the reduction of chromium(VI) to chromium(III). The second process includes the direct binding of chromium(V), produced by reduction in the cell, and chromium(IV) compounds to the DNA. The last mechanism attributed the genotoxicity to the binding to the DNA of the end product of the chromium(III) reduction.
Chromium salts (chromates) are also the cause of allergic reactions in some people. Chromates are often used to manufacture, amongst other things, leather products, paints, cement, mortar and anti-corrosives. Contact with products containing chromates can lead to allergic contact dermatitis and irritant dermatitis, resulting in ulceration of the skin, sometimes referred to as “chrome ulcers”. This condition is often found in workers that have been exposed to strong chromate solutions in electroplating, tanning and chrome-producing manufacturers.
Detection of Chromates
API’s Food Poison Detection Kit includes everything one needs to conduct a complete analysis of food for all the most notorious poisons, document the results and preserve any evidence. This Kit was developed under a research grant with the U.S. Department of Defense and has been validated by multiple parties.
The ChemSee CN-30 Chromate Detection Tab offers detectors designed for easy, home-based detection of Cyanide and Chromates in food and drink. Simple, color-based test results are obtained in 3 seconds to 3 minutes. Simply put three to five droplets of the liquid drink sample to the card and watch for blue color to form if Chromates are in the sample. Instructions for preparing samples of solid food for testing are included with each purchase. This simple, low-cost test for Chromates is the only test available on the market that can be used at home that provides instant results.
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